Gradual phosphorylation regulates PC4 coactivator function
نویسندگان
چکیده
منابع مشابه
Phosphorylation Regulates SIRT1 Function
BACKGROUND SIR2 is an NAD(+)-dependent deacetylase [1]-[3] implicated in the regulation of lifespan in species as diverse as yeast [4], worms [5], and flies [6]. We previously reported that the level of SIRT1, the mammalian homologue of SIR2 [7], [8], is coupled to the level of mitotic activity in cells both in vitro and in vivo[9]. Cells from long-lived mice maintained SIRT1 levels of young mi...
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Smads are intermediate effector proteins that transduce the TGF-b signal from the plasma membrane to the nucleus, where they participate in transactivation of downstream target genes. We have shown previously that coactivators p300/CREB-binding protein are involved in TGF-b–mediated transactivation of two Cdk inhibitor genes, p21 and p15. Here we examined the possibility that Smads function to ...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2006
ISSN: 1742-464X,1742-4658
DOI: 10.1111/j.1742-4658.2006.05165.x